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Probing the Lower Size Limit for Protein-like Fold Stability: Ten-residue Microproteins Greater than 97% Folded in Water at 280K
Mutational optimization of two long-range interactions first observed in Ac-WINGKWT-NH(2) – a) bifurcated H-bonding involving the threonine amide H(N) and sidechain OH and the N-terminal acetyl carbonyl and b) an H-bond between the entgegen-H(N) of the C-terminal amide and the indole ring of Trp6 wh...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2677142/ https://ncbi.nlm.nih.gov/pubmed/18842046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja804656h |
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