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Circular Permutation of the Trp-cage: Fold Rescue upon Addition of a Hydrophobic Staple
The Trp-cage, at 20 residues in length, is generally acknowledged as the smallest fully protein-like folding motif. Linking the termini by a two-residue unit and excising one residue affords circularly permuted sequences that adopt the same structure. This represents the first successful circular pe...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3870897/ https://ncbi.nlm.nih.gov/pubmed/24376912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3RA43674H |
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