HLA-B27 misfolding and spondyloarthropathies

HLA-B27 plays a central role in the pathogenesis of many spondyloarthropathies and in particular ankylosing spondylitis. The observation that the HLA-B27 heavy chain has a tendency to misfold has raised the possibility that associated diseases may belong in a rapidly expanding category of protein mi...

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Bibliographic Details
Main Authors: Colbert, Robert A, DeLay, Monica L, Layh-Schmitt, Gerlinde, Sowders, Dawn P
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2009
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676739/
https://ncbi.nlm.nih.gov/pubmed/19363299
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