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HLA-B27 Misfolding and the Unfolded Protein Response Augment IL-23 Production and are Associated with Th17 Activation in Transgenic Rats

OBJECTIVE: To determine whether HLA-B27 misfolding and the unfolded protein response (UPR) results in cytokine dysregulation, and whether this is associated with Th1 and/or Th17 activation in HLA-B27/human beta-2-microglobulin (hβ(2)m) transgenic rats (HLA-B27 transgenic), an animal model of spondyl...

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Hlavní autoři: DeLay, Monica L., Turner, Matthew J., Klenk, Erin I., Smith, Judith A., Sowders, Dawn P., Colbert, Robert A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893331/
https://ncbi.nlm.nih.gov/pubmed/19714651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24763
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