Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

Macroautophagy, a major pathway for organelle and protein turnover, has been implicated in the neurodegeneration of Alzheimer's disease (AD). The basis for the profuse accumulation of autophagic vacuoles (AVs) in affected neurons of the AD brain, however, is unknown. In this study, we show that...

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Main Authors: Boland, Barry, Kumar, Asok, Lee, Sooyeon, Platt, Frances M., Wegiel, Jerzy, Yu, W. Haung, Nixon, Ralph A.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2008
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676733/
https://ncbi.nlm.nih.gov/pubmed/18596167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0800-08.2008
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