Structural and Functional Dissection of the Heterocyclic Peptide Cytotoxin Streptolysin S

The human pathogen Streptococcus pyogenes secretes a highly cytolytic toxin known as streptolysin S (SLS). SLS is a key virulence determinant and responsible for the β-hemolytic phenotype of these bacteria. Despite over a century of research, the chemical structure of SLS remains unknown. Recent exp...

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Detalhes bibliográficos
Main Authors: Mitchell, Douglas A., Lee, Shaun W., Pence, Morgan A., Markley, Andrew L., Limm, Joyce D., Nizet, Victor, Dixon, Jack E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676033/
https://ncbi.nlm.nih.gov/pubmed/19286651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900802200
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