Sec61p Is Required for ERAD-L: GENETIC DISSECTION OF THE TRANSLOCATION AND ERAD-L FUNCTIONS OF Sec61P USING NOVEL DERIVATIVES OF CPY

Misfolded proteins in the endoplasmic reticulum (ER) are exported to the cytosol for degradation by the proteasome in a process known as ER-associated degradation (ERAD). CPY* is a well characterized ERAD substrate whose degradation is dependent upon the Hrd1 complex. However, although the functions...

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Detalhes bibliográficos
Main Authors: Willer, Martin, Forte, Gabriella M. A., Stirling, Colin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590686/
https://ncbi.nlm.nih.gov/pubmed/18819915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803054200
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