The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range

AIMS: To establish whether the effect of SLCO1B1[encoding organic anion transporting polypeptide 1B1 (OATP1B1)] c.521T→C (p.Val174Ala) polymorphism on the pharmacokinetics of repaglinide is dose-dependent. METHODS: Twelve healthy volunteers with the SLCO1B1 c.521TT genotype (controls) and eight with...

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Detalhes bibliográficos
Main Authors: Kalliokoski, Annikka, Neuvonen, Mikko, Neuvonen, Pertti J, Niemi, Mikko
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Pharmacogenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675779/
https://ncbi.nlm.nih.gov/pubmed/18823304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03287.x
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