Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes

AIMS: Our aim was to investigate associations between the single nucleotide polymorphisms (SNPs) in the SLCO1B1 (encoding OATP1B1) and ABCB1 (encoding P-glycoprotein) genes with the pharmacokinetics and efficacy of pravastatin in children with heterozygous familial hypercholesterolaemia (HeFH) and i...

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Autori principali: Hedman, Mia, Antikainen, Marjatta, Holmberg, Christer, Neuvonen, Mikko, Eichelbaum, Michel, Kivistö, Kari T, Neuvonen, Pertti J, Niemi, Mikko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2006
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885108/
https://ncbi.nlm.nih.gov/pubmed/16722833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02643.x
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