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Membrane cholesterol content influences binding properties of muscarinic M(2) receptors and differentially impacts activation of second messenger pathways
We investigated the influence of membrane cholesterol content on preferential and non-preferential signaling through the M(2) muscarinic acetylcholine receptor expressed in CHO cells. Cholesterol depletion by 39% significantly decreased the affinity of M(2) receptors for [(3)H]-N-methylscopolamine (...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2675699/ https://ncbi.nlm.nih.gov/pubmed/19374848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2009.01.028 |
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