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Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M(1) and M(4) Subtypes of Muscarinic Acetylcholine Receptors

Xanomeline is an agonist endowed with functional preference for M(1)/M(4) muscarinic acetylcholine receptors. It also exhibits both reversible and wash-resistant binding to and activation of these receptors. So far the mechanisms of xanomeline selectivity remain unknown. To address this question we...

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Hlavní autoři: Šantrůčková, Eva, Doležal, Vladimír, El-Fakahany, Esam E., Jakubík, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928307/
https://ncbi.nlm.nih.gov/pubmed/24558448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088910
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