Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2)

The ubiquitin-conjugating enzyme E2-25K has been identified as a huntingtin (the key protein in Huntington’s disease) interacting protein and has been shown to play a role in mediating the toxicity of Aβ, the principal protein involved in Alzheimer’s disease pathogenesis. E2-25K is a dual-domain pro...

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Bibliographic Details
Main Authors: Wilson, Randall C., Hughes, Ronny C., Flatt, Justin W., Meehan, Edward J., Ng, Joseph D., Twigg, Pamela D.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2009
Subjects:
Structural Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675580/
https://ncbi.nlm.nih.gov/pubmed/19407372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109011117
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