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PDZ Domain Binding Selectivity Is Optimized Across the Mouse Proteome
PDZ domains have long been thought to cluster into discrete functional classes defined by their peptide-binding preferences. We used protein microarrays and quantitative fluorescence polarization to characterize the binding selectivity of 157 mouse PDZ domains with respect to 217 genome-encoded pept...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2674608/ https://ncbi.nlm.nih.gov/pubmed/17641200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1144592 |
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