PDZ Domain Binding Selectivity Is Optimized Across the Mouse Proteome

PDZ domains have long been thought to cluster into discrete functional classes defined by their peptide-binding preferences. We used protein microarrays and quantitative fluorescence polarization to characterize the binding selectivity of 157 mouse PDZ domains with respect to 217 genome-encoded pept...

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Détails bibliographiques
Auteurs principaux: Stiffler, Michael A., Chen, Jiunn R., Grantcharova, Viara P., Lei, Ying, Fuchs, Daniel, Allen, John E., Zaslavskaia, Lioudmila A., MacBeath, Gavin
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674608/
https://ncbi.nlm.nih.gov/pubmed/17641200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1144592
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