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Small molecule versus DNA repair nanomachine
The MRN protein megacomplex mediates repair of double-stranded DNA breaks (DSBs) by tethering together broken ends of chromosomes and signaling a cascade of events required for DNA repair. The first small-molecule inhibitor that disrupts MRN function provides a valuable new tool for functional studi...
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| Autor principal: | |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2674310/ https://ncbi.nlm.nih.gov/pubmed/18202674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio0208-86 |
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