Isolation of a small molecule inhibitor of DNA base excision repair

The base excision repair (BER) pathway is essential for the removal of DNA bases damaged by alkylation or oxidation. A key step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP endonuclease. The major AP endonuclease in human cells (APE1, also termed HAP1 and Ref-...

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主要な著者: Madhusudan, Srinivasan, Smart, Fiona, Shrimpton, Paul, Parsons, Jason L., Gardiner, Laurence, Houlbrook, Sue, Talbot, Denis C., Hammonds, Timothy, Freemont, Paul A., Sternberg, Michael J. E., Dianov, Grigory L., Hickson, Ian D.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2005
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Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1188083/
https://ncbi.nlm.nih.gov/pubmed/16113242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki781
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