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Small Molecule Inhibitors of DNA Repair Nuclease Activities of APE1
APE1 is a multifunctional protein that possesses several nuclease activities, including the ability to incise at apurinic/apyrimidinic (AP) sites in DNA or RNA, to excise 3’-blocking termini from DNA ends, and to cleave at certain oxidized base lesions in DNA. Pre-clinical and clinical data indicate...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2956791/ https://ncbi.nlm.nih.gov/pubmed/20809131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0488-2 |
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