Small-molecule Inhibitors of Bacterial AddAB and RecBCD Helicase-nuclease DNA Repair Enzymes

The AddAB and RecBCD helicase-nucleases are related enzymes prevalent among bacteria but not eukaryotes and are instrumental in the repair of DNA double-strand breaks and in genetic recombination. Although these enzymes have been extensively studied both genetically and biochemically, inhibitors spe...

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Bibliographic Details
Main Authors: Amundsen, Susan K., Spicer, Timothy, Karabulut, Ahmet C., Londoño, Luz Marina, Eberhardt, Christina, Vega, Virneliz Fernandez, Bannister, Thomas D., Hodder, Peter, Smith, Gerald R.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356449/
https://ncbi.nlm.nih.gov/pubmed/22443934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300018x
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