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Structure of the cytosine–cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycin

The structure of a cytosine–cytosine (CC) mismatch-containing RNA molecule derived from a hairpin structure in the thymidylate synthase mRNA that binds the aminoglycoside paromomycin with high affinity was determined using nuclear magnetic resonance (NMR) spectroscopy. The cytosines in the mismatch...

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Detalhes bibliográficos
Main Authors: Tavares, Tony J., Beribisky, Alexander V., Johnson, Philip E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673063/
https://ncbi.nlm.nih.gov/pubmed/19329536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1514909
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