Specific binding of Hoechst 33258 to site 1 thymidylate synthase mRNA

The translational initiator codon in thymidylate synthetase (TS) mRNA is located in a stem–loop structure with a CC bubble. TS is an important target for anticancer drugs. Aminoglycoside antibiotics have been shown to specifically bind to TS mRNA site 1 constructs and, furthermore, specific binding...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Cho, Junhyeong, Rando, Robert R.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2000
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105371/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10773086/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.10.2158
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