Activation and Desensitization of Nicotinic α7-type Acetylcholine Receptors by Benzylidene Anabaseines and Nicotine

Nicotinic receptor activation is inextricably linked to desensitization. This duality affects our ability to develop useful therapeutics targeting nicotinic acetylcholine receptor (nAChR). Nicotine and some α7-selective experimental partial agonists produce a transient activation of α7 receptors fol...

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Bibliografiske detaljer
Main Authors: Papke, Roger L., Kem, William R., Soti, Ferenc, López-Hernández, Gretchen Y., Horenstein, Nicole A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Pharmacology and Experimental Therapeutics 2009
Fag:
Neuropharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672872/
https://ncbi.nlm.nih.gov/pubmed/19223664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.150151
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