PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation

In chondrocytes, PTHrP maintains them in a proliferative state and prevents premature hypertrophy. The mechanism by which PTHrP does this is not fully understood. Both Runx2 and Runx3 are required for chondrocyte maturation. We recently demonstrated that cyclin D1 induces Runx2 protein phosphorylati...

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Autori principali: Zhang, Ming, Xie, Rong, Hou, Wei, Wang, Baoli, Shen, Run, Wang, Xiumei, Wang, Qing, Zhu, Tianhui, Jonason, Jennifer H., Chen, Di
Natura: Artigo
Lingua:Inglês
Pubblicazione: Company of Biologists 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671927/
https://ncbi.nlm.nih.gov/pubmed/19351720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.040709
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