Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces
A general strategy is described for improving the binding properties of small-molecule ligands to protein targets. A bifunctional molecule is created by chemically linking a ligand of interest to another small molecule that binds tightly to a second protein. When the ligand of interest is presented...
Na minha lista:
| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26718/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.1953 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|