An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models

Tumor necrosis factor-α (TNF-α) is a key mediator of inflammatory diseases, including rheumatoid arthritis (RA), and anti–TNF-α drugs such as etanercept are effective treatments. Splice-switching oligonucleotides (SSOs) are a new class of drugs designed to induce therapeutically favorable splice var...

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Detalhes bibliográficos
Main Authors: Graziewicz, Maria A, Tarrant, Teresa K, Buckley, Brian, Roberts, Jennifer, Fulton, LeShara, Hansen, Henrik, Ørum, Henrik, Kole, Ryszard, Sazani, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671678/
https://ncbi.nlm.nih.gov/pubmed/18461057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.85
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