Lowering Blood Pressure Blocks Mesangiolysis and Mesangial Nodules, but Not Tubulointerstitial Injury, in Diabetic eNOS Knockout Mice

Recently, we and others reported that diabetic endothelial nitric oxide synthase knockout (eNOSKO) mice develop advanced glomerular lesions that include mesangiolysis and nodular lesions. Interestingly, insulin treatment lowered blood pressure and prevented renal lesions, raising the question as to...

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Main Authors: Kosugi, Tomoki, Heinig, Marcelo, Nakayama, Takahiro, Connor, Thomas, Yuzawa, Yukio, Li, Qiuhong, Hauswirth, William W., Grant, Maria B., Croker, Byron P., Campbell-Thompson, Martha, Zhang, Li, Atkinson, Mark A., Segal, Mark S., Nakagawa, Takahiko
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2009
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671355/
https://ncbi.nlm.nih.gov/pubmed/19246639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080605
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