Lowering Blood Pressure Blocks Mesangiolysis and Mesangial Nodules, but Not Tubulointerstitial Injury, in Diabetic eNOS Knockout Mice

Recently, we and others reported that diabetic endothelial nitric oxide synthase knockout (eNOSKO) mice develop advanced glomerular lesions that include mesangiolysis and nodular lesions. Interestingly, insulin treatment lowered blood pressure and prevented renal lesions, raising the question as to...

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Autori principali: Kosugi, Tomoki, Heinig, Marcelo, Nakayama, Takahiro, Connor, Thomas, Yuzawa, Yukio, Li, Qiuhong, Hauswirth, William W., Grant, Maria B., Croker, Byron P., Campbell-Thompson, Martha, Zhang, Li, Atkinson, Mark A., Segal, Mark S., Nakagawa, Takahiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2009
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671355/
https://ncbi.nlm.nih.gov/pubmed/19246639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080605
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