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Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice

Hyperuricemia has recently been recognized to be a risk factor for nephropathy in the diabetic subject. We tested the hypothesis that lowering uric acid with a xanthine oxidase inhibitor might reduce renal injury in the diabetic mouse. Diabetic (db/db) mice were treated with allopurinol or no treatm...

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Detalhes bibliográficos
Main Authors: Kosugi, Tomoki, Nakayama, Takahiro, Heinig, Marcelo, Zhang, Li, Yuzawa, Yukio, Sanchez-Lozada, Laura Gabriela, Roncal, Carlos, Johnson, Richard J., Nakagawa, Takahiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724243/
https://ncbi.nlm.nih.gov/pubmed/19458127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00092.2009
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