Lowering Blood Pressure Blocks Mesangiolysis and Mesangial Nodules, but Not Tubulointerstitial Injury, in Diabetic eNOS Knockout Mice

Recently, we and others reported that diabetic endothelial nitric oxide synthase knockout (eNOSKO) mice develop advanced glomerular lesions that include mesangiolysis and nodular lesions. Interestingly, insulin treatment lowered blood pressure and prevented renal lesions, raising the question as to...

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Detalhes bibliográficos
Main Authors: Kosugi, Tomoki, Heinig, Marcelo, Nakayama, Takahiro, Connor, Thomas, Yuzawa, Yukio, Li, Qiuhong, Hauswirth, William W., Grant, Maria B., Croker, Byron P., Campbell-Thompson, Martha, Zhang, Li, Atkinson, Mark A., Segal, Mark S., Nakagawa, Takahiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671355/
https://ncbi.nlm.nih.gov/pubmed/19246639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080605
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