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Deficient DNA Mismatch Repair Is Common in Lynch Syndrome-Associated Colorectal Adenomas
Lynch syndrome is caused by germline mutations in DNA mismatch repair (MMR) genes. Both microsatellite instability (MSI) testing and immunohistochemical analyses (IHC) of colon cancers are valuable diagnostic strategies for Lynch syndrome. We sought to determine whether these markers of MMR deficien...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Investigative Pathology
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2671341/ https://ncbi.nlm.nih.gov/pubmed/19324997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2009.080142 |
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