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The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome
The majority of Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer (HNPCC), has been linked to heterozygous defects in DNA mismatch repair (MMR). MMR is a highly conserved pathway that recognizes and repairs polymerase misincorporation errors and nucleotide damage as well...
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| Publicado no: | Fam Cancer |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4235668/ https://ncbi.nlm.nih.gov/pubmed/23572416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-013-9635-x |
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