Deficient DNA Mismatch Repair Is Common in Lynch Syndrome-Associated Colorectal Adenomas

Lynch syndrome is caused by germline mutations in DNA mismatch repair (MMR) genes. Both microsatellite instability (MSI) testing and immunohistochemical analyses (IHC) of colon cancers are valuable diagnostic strategies for Lynch syndrome. We sought to determine whether these markers of MMR deficien...

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Detalhes bibliográficos
Main Authors: Pino, Maria Simona, Mino-Kenudson, Mari, Wildemore, Bernadette Mandes, Ganguly, Aniruddha, Batten, Julie, Sperduti, Isabella, Iafrate, Anthony John, Chung, Daniel C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671341/
https://ncbi.nlm.nih.gov/pubmed/19324997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2009.080142
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