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Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

OBJECTIVE: We have previously reported a highly diabetogenic CD8 T-cell clone, G9C8, in the nonobese diabetic (NOD) mouse, specific to low-avidity insulin peptide B15-23, and cells responsive to this antigen are among the earliest islet infiltrates. We aimed to study the selection, activation, and d...

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Bibliografske podrobnosti
Main Authors: Wong, F. Susan, Khai Siew, Lai, Scott, Gwen, Thomas, Ian J., Chapman, Stephen, Viret, Christophe, Wen, Li
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671054/
https://ncbi.nlm.nih.gov/pubmed/19208910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0800
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