Altered Gut Microbiota Activate and Expand Insulin B15-23–Reactive CD8+ T Cells

Insulin is a major autoantigen in type 1 diabetes, targeted by both CD8 and CD4 T cells. We studied an insulin-reactive T-cell receptor (TCR) α-chain transgenic NOD mouse on a TCRCα and proinsulin 2 (PI2)-deficient background, designated as A22Cα(−/−)PI2(−/−) NOD mice. These mice develop a low incid...

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Vydáno v:Diabetes
Hlavní autoři: Pearson, James A., Kakabadse, Dimitri, Davies, Joanne, Peng, Jian, Warden-Smith, Jeremy, Cuff, Simone, Lewis, Mark, da Rosa, Larissa Camargo, Wen, Li, Wong, F. Susan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2019
Témata:
Immunology and Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477900/
https://ncbi.nlm.nih.gov/pubmed/30796028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0487
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