IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse

Autoimmune diabetes is characterized by autoantigen-specific T cell-mediated destruction of pancreatic islet beta cells, and CD8(+) T cells are key players during this process. We assessed whether the bitransgenic RIP-CD80 x RIP-LCMV-GP (RIP-CD80GP) mice may be a versatile antigen-specific model of...

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Autores principales: Fuchs, Y F, Adler, K, Lindner, A, Karasinsky, A, Wilhelm, C, Weigelt, M, Balke, H, Förtsch, K, Mortler-Hildebrandt, L F, Harlan, D M, Pechhold, K, Ziegler, A-G, Bonifacio, E
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992032/
https://ncbi.nlm.nih.gov/pubmed/24387268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12263
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