CD8(+) T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage

CD8(+) T cells directed against beta cell autoantigens are considered relevant for the pathogenesis of type 1 diabetes. Using single cell T cell receptor sequencing of CD8(+) T cells specific for the IGRP(265-273) epitope, we examined whether there was expansion of clonotypes and sharing of T cell r...

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Vydáno v:Sci Rep
Hlavní autoři: Fuchs, Yannick F., Eugster, Anne, Dietz, Sevina, Sebelefsky, Christian, Kühn, Denise, Wilhelm, Carmen, Lindner, Annett, Gavrisan, Anita, Knoop, Jan, Dahl, Andreas, Ziegler, Anette-G., Bonifacio, Ezio
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353542/
https://ncbi.nlm.nih.gov/pubmed/28300170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44661
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