Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice

OBJECTIVE: Interleukin (IL)-21 is a type 1 cytokine that has been implicated in the pathogenesis of type 1 diabetes via the unique biology of the nonobese diabetic (NOD) mouse strain. The aim of this study was to investigate a causal role for IL-21 in type 1 diabetes. RESEARCH DESIGN AND METHODS: We...

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Bibliographic Details
Main Authors: Sutherland, Andrew P.R., Van Belle, Tom, Wurster, Andrea L., Suto, Akira, Michaud, Monia, Zhang, Dorothy, Grusby, Michael J., von Herrath, Matthias
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2009
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671036/
https://ncbi.nlm.nih.gov/pubmed/19208913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0882
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