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Interleukin-21 Receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets
SUMMARY: It remains unclear how interleukin-21 receptor (IL-21R) contributes to type 1 diabetes. Here we have shown that dendritic cells (DCs) in the pancreas required IL-21R, not for antigen uptake, but to acquire the chemokine receptor CCR7 and migrate into the draining lymph node. Consequently, l...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3810457/ https://ncbi.nlm.nih.gov/pubmed/22579473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.04.005 |
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