Highly Twisted Adamantyl Arotinoids: Synthesis, Antiproliferative Effects and RXR Transactivation Profiles

Retinoid-related molecules with an adamantyl group (adamantyl arotinoids) have been described with selective activities towards the retinoid receptors as agonists for NR1B2 and NR1B3 (RARβ,γ) (CD437, MX3350-1) or RAR antagonists (MX781) that induce growth arrest and apoptosis in cancer cells. Since...

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Autors principals: Pérez-Rodríguez, Santiago, Ortiz, Maria A., Pereira, Raquel, Rodríguez-Barrios, Fátima, de Lera, Ángel R., Piedrafita, F. Javier
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670958/
https://ncbi.nlm.nih.gov/pubmed/19216008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2009.01.011
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