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Control of telomere length by a trimming mechanism that involves generation of t-circles

Telomere lengths are maintained in many cancer cells by the ribonucleoprotein enzyme telomerase but can be further elongated by increasing telomerase activity through the overexpression of telomerase components. We report here that increased telomerase activity results in increased telomere length t...

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Detalhes bibliográficos
Main Authors: Pickett, Hilda A, Cesare, Anthony J, Johnston, Rebecca L, Neumann, Axel A, Reddel, Roger R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670870/
https://ncbi.nlm.nih.gov/pubmed/19214183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.42
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