Five dysfunctional telomeres predict onset of senescence in human cells

Replicative senescence is accompanied by a telomere-specific DNA damage response (DDR). We found that DDR+ telomeres occur spontaneously in early-passage normal human cells and increase in number with increasing cumulative cell divisions. DDR+ telomeres at replicative senescence retain TRF2 and RAP1...

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Bibliografske podrobnosti
Main Authors: Kaul, Zeenia, Cesare, Anthony J, Huschtscha, Lily I, Neumann, Axel A, Reddel, Roger R
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Scientific Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246253/
https://ncbi.nlm.nih.gov/pubmed/22157895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.227
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