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Five dysfunctional telomeres predict onset of senescence in human cells
Replicative senescence is accompanied by a telomere-specific DNA damage response (DDR). We found that DDR+ telomeres occur spontaneously in early-passage normal human cells and increase in number with increasing cumulative cell divisions. DDR+ telomeres at replicative senescence retain TRF2 and RAP1...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3246253/ https://ncbi.nlm.nih.gov/pubmed/22157895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.227 |
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