Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell–depleted allogeneic hematopoietic cell transplantation

Alloreactive natural killer (NK) cells are an important influence on hematopoietic stem cell transplantation (HSCT) outcome. In HLA-mismatched HSCT, alloreactivity occurs when licensed donor NK cells expressing inhibitory killer Ig-like receptors (KIR) for donor MHC class I ligands recognize the lac...

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Autori principali: Yu, Junli, Venstrom, Jeffrey M., Liu, Xiao-Rong, Pring, James, Hasan, Reenat S., O'Reilly, Richard J., Hsu, Katharine C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2009
Soggetti:
Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670800/
https://ncbi.nlm.nih.gov/pubmed/19179302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-177055
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