ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

ADAM10 is involved in the proteolytic processing and shedding of proteins such as the amyloid precursor protein (APP), cadherins, and the Notch receptors, thereby initiating the regulated intramembrane proteolysis (RIP) of these proteins. Here, we demonstrate that the sheddase ADAM10 is also subject...

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Bibliografiset tiedot
Päätekijät: Tousseyn, Thomas, Thathiah, Amantha, Jorissen, Ellen, Raemaekers, Tim, Konietzko, Uwe, Reiss, Karina, Maes, Elke, Snellinx, An, Serneels, Lutgarde, Nyabi, Omar, Annaert, Wim, Saftig, Paul, Hartmann, Dieter, De Strooper, Bart
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
Enzyme Catalysis and Regulation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670177/
https://ncbi.nlm.nih.gov/pubmed/19213735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805894200
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