ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

ADAM10 is involved in the proteolytic processing and shedding of proteins such as the amyloid precursor protein (APP), cadherins, and the Notch receptors, thereby initiating the regulated intramembrane proteolysis (RIP) of these proteins. Here, we demonstrate that the sheddase ADAM10 is also subject...

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Autori principali: Tousseyn, Thomas, Thathiah, Amantha, Jorissen, Ellen, Raemaekers, Tim, Konietzko, Uwe, Reiss, Karina, Maes, Elke, Snellinx, An, Serneels, Lutgarde, Nyabi, Omar, Annaert, Wim, Saftig, Paul, Hartmann, Dieter, De Strooper, Bart
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Enzyme Catalysis and Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670177/
https://ncbi.nlm.nih.gov/pubmed/19213735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805894200
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