p53 Acetylation Is Crucial for Its Transcription-independent Proapoptotic Functions

Acetylation of p53 at carboxyl-terminal lysine residues enhances its transcriptional activity associated with cell cycle arrest and apoptosis. Here we demonstrate that p53 acetylation at Lys-320/Lys-373/Lys-382 is also required for its transcription-independent functions in BAX activation, reactive...

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Main Authors: Yamaguchi, Hirohito, Woods, Nicholas T., Piluso, Landon G., Lee, Heng-Huan, Chen, Jiandong, Bhalla, Kapil N., Monteiro, Alvaro, Liu, Xuan, Hung, Mien-Chie, Wang, Hong-Gang
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Protein Synthesis, Post-Translational Modification, and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670122/
https://ncbi.nlm.nih.gov/pubmed/19265193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809268200
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