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FGF15/FGFR4 Integrates Growth Factor Signaling with Hepatic Bile Acid Metabolism and Insulin Action

The current studies show FGF15 signaling decreases hepatic forkhead transcription factor 1 (FoxO1) activity through phosphatidylinositol (PI) 3-kinase-dependent phosphorylation. The bile acid receptor FXR (farnesoid X receptor) activates expression of fibroblast growth factor (FGF) 15 in the intesti...

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Detalhes bibliográficos
Main Authors: Shin, Dong-Ju, Osborne, Timothy F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670116/
https://ncbi.nlm.nih.gov/pubmed/19237543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808747200
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