Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Activation of CYP7A1 during Food Restriction and Diabetes Is Still Inhibited by Small Heterodimer Partner

Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the rate-limiting step in the classic pathway of hepatic bile acid biosynthesis from cholesterol. During fasting and in type I diabetes, elevated levels of peroxisome proliferator-activated receptor γ-coactivator-1α (PGC-1α) induce expression of the Cyp7...

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Hlavní autoři: Shin, Dong-Ju, Osborne, Timothy F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397466/
https://ncbi.nlm.nih.gov/pubmed/18385139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710452200
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