An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

Bile acid synthesis plays a key role in regulating whole body cholesterol homeostasis. Transcriptional factor EB (TFEB) is a nutrient and stress-sensing transcriptional factor that promotes lysosomal biogenesis. Here we report a role of TFEB in regulating hepatic bile acid synthesis. We show that TF...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Yifeng, Gunewardena, Sumedha, Li, Feng, Matye, David J., Chen, Cheng, Chao, Xiaojuan, Jung, Taeyoon, Zhang, Yuxia, Czerwiński, Maciej, Ni, Hong-Min, Ding, Wen-Xing, Li, Tiangang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368063/
https://ncbi.nlm.nih.gov/pubmed/32681035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17363-6
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