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PPARδ agonism inhibits skeletal muscle PDC activity, mitochondrial ATP production and force generation during prolonged contraction

We have recently shown that PPARδ agonism, used clinically to treat insulin resistance, increases fat oxidation and up-regulates mitochondrial PDK4 mRNA and protein expression in resting skeletal muscle. We hypothesized that PDK4 up-regulation, which inhibits pyruvate dehydrogenase complex (PDC)-dep...

詳細記述

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書誌詳細
主要な著者: Constantin-Teodosiu, Dumitru, Baker, David J, Constantin, Despina, Greenhaff, Paul L
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Science Inc 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670036/
https://ncbi.nlm.nih.gov/pubmed/19001043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.164210
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