The Role of FOXO and PPAR Transcription Factors in Diet-Mediated Inhibition of PDC Activation and Carbohydrate Oxidation During Exercise in Humans and the Role of Pharmacological Activation of PDC in Overriding These Changes

High-fat feeding inhibits pyruvate dehydrogenase complex (PDC)–controlled carbohydrate (CHO) oxidation, which contributes to muscle insulin resistance. We aimed to reveal molecular changes underpinning this process in resting and exercising humans. We also tested whether pharmacological activation o...

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Main Authors: Constantin-Teodosiu, Dumitru, Constantin, Despina, Stephens, Francis, Laithwaite, David, Greenhaff, Paul L.
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2012
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331777/
https://ncbi.nlm.nih.gov/pubmed/22315317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0799
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