PPARδ agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle

PPARα agonism impairs mitochondrial function, but the effect of PPARδ agonism on mitochondrial function is equivocal. Furthermore, PPARα and δ agonism increases muscle fatty acid oxidation, potentially via activation of FOXO1 signalling and PDK4 transcription. Since FOXO1 activation has also been su...

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Bibliographische Detailangaben
Hauptverfasser: Constantin, Despina, Constantin-Teodosiu, Dumitru, Layfield, Robert, Tsintzas, Kostas, Bennett, Andrew J, Greenhaff, Paul L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2007
Schlagworte:
Integrative
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277240/
https://ncbi.nlm.nih.gov/pubmed/17540700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.135459
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