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PPARδ agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle

PPARα agonism impairs mitochondrial function, but the effect of PPARδ agonism on mitochondrial function is equivocal. Furthermore, PPARα and δ agonism increases muscle fatty acid oxidation, potentially via activation of FOXO1 signalling and PDK4 transcription. Since FOXO1 activation has also been su...

詳細記述

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書誌詳細
主要な著者: Constantin, Despina, Constantin-Teodosiu, Dumitru, Layfield, Robert, Tsintzas, Kostas, Bennett, Andrew J, Greenhaff, Paul L
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Science Inc 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277240/
https://ncbi.nlm.nih.gov/pubmed/17540700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.135459
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