PPARδ agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle

PPARα agonism impairs mitochondrial function, but the effect of PPARδ agonism on mitochondrial function is equivocal. Furthermore, PPARα and δ agonism increases muscle fatty acid oxidation, potentially via activation of FOXO1 signalling and PDK4 transcription. Since FOXO1 activation has also been su...

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Detalhes bibliográficos
Main Authors: Constantin, Despina, Constantin-Teodosiu, Dumitru, Layfield, Robert, Tsintzas, Kostas, Bennett, Andrew J, Greenhaff, Paul L
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
Assuntos:
Integrative
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277240/
https://ncbi.nlm.nih.gov/pubmed/17540700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.135459
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