Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products
The structures of complex polyketide natural products, such as erythromycin, are programmed by multifunctional polyketide synthases (PKSs) that contain modular arrangements of functional domains. The colinearity between the activities of modular PKS domains and structure of the polyketide product po...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
1999
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26699/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051557/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.1846 |
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