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Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products

The structures of complex polyketide natural products, such as erythromycin, are programmed by multifunctional polyketide synthases (PKSs) that contain modular arrangements of functional domains. The colinearity between the activities of modular PKS domains and structure of the polyketide product po...

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: McDaniel, Robert, Thamchaipenet, Arinthip, Gustafsson, Claes, Fu, Hong, Betlach, Melanie, Betlach, Mary, Ashley, Gary
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 1999
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26699/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051557/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.1846
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